A personalized nutritional approach, based not only on phenotypic traits but also on genetic make-up, may help to control body weight and obesity. The investigations into genetic variation across the human genome have revealed that about 25 - 70% of body weight variability is under genetic inﬂuence, and that more than 600 chromosomal regions may be involved in the heritability of obesity. A number of studies have focused on genes regulating energy intake, lipid metabolism and adipo cytokine synthesis as well as important transcription factors whose functions may be inﬂuenced by energy restriction and dietary intake and, therefore, may have an impact on body composition and weight gain.
For example, the rs894160 gene variant of PLIN1 has been associated with changes in abdominal fat reduction following a hypocaloric diet prescribed for mildly weight loss. Moreover, PLIN1 11482A carriers of the rs894160 polymorphism were apparently resistant to weight loss. In this context, it is necessary to focus on personalized phenotypes and singular traits in every subject, including allergies, likes and dislikes, as well as on the genetic background instead of just focusing on healthy eating.
Full article: https://www.researchgate.net/publication/270664177_Genetics_of_weight_loss_A_basis_for_personalized_obesity_management